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I have: fully professional explained to the patient, the nature and purpose of isotretinoin treatment, including its benefits and risks given the patient the appropriate educational materials, The ipledge Program Patient Introductory Brochure and asked the patient if he/she has any questions. Marked elevations of serum triglycerides were reported in approximately 25 of patients receiving Accutane in clinical trials. But UK dermatologist Tony Chu said that often Roaccutane is being offered far more than that:2 roaccutane is grossly overused I've seen patients who have been to see a local dermatologist to treat four of five spots. Tiredness, tenderness or stiffness of bones, joints and muscles These vary greatly between patients, and are dose-and activity-related (improve or resolve with activity modification accutane and/or dose reduction over days to weeks). 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